Leucocyte electrolytes and sodium efllux rate constants in the hypertension
ثبت نشده
چکیده
1. Leucocyte electrolytes were measured in pre-eclampsia and comparison was made with leucocytes from normal primigravidae and from the original pre-eclamptic subjects 6 months after delivery when blood pressure had returned to normal. 2. In pre-eclamptic subjects, leucocyte sodium was elevated and potassium depressed, and the rate constant for sodium efflux was depressed. 3. These changes returned to normal after delivery. 4. An increase in cellular sodium as a result of altered sodium pump activity may be the cause of hyperttnsion in pre-eclampsia.
منابع مشابه
Sodium, potassium, and rate constants for sodium efflux in leucocytes from hypertensive Jamaicans.
Leucocyte sodium and potassium content and concentrations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension. Leucocyte sodium content was significantly increased in the patients (mean 101.1 +/- 7.8 mmol/kg dry solids v 74.5 +/- 7.6 mmol/kg dry solids; p less than 0.05), whereas the...
متن کاملChanges in leucocyte sodium transport in normotensive relatives of hypertensive subjects. Dissociation from blood pressure.
It has been postulated that depressed membrane sodium transport is a necessary step in blood pressure elevation in essential hypertension. Accordingly, leucocyte sodium efflux-rate constants were estimated in 14 normotensive subjects who had one or more first-degree relatives with essential hypertension, and also in 14 matched control subjects with no such family history, before and after takin...
متن کاملChanges in Leucocyte Sodium Transport in Normotensive Relatives of Hypertensive Subjects
It has been postulated that depressed membrane sodium transport is a necessary step in blood pressure elevation in essential hypertension. Accordingly, leucocyte sodium efflux-rate constants were estimated in 14 normotensive subjects who had one or more first-degree relatives with essential hypertension, and also in 14 matched control subjects with no such family history, before and after takin...
متن کاملCHANGES IN BLOOD LEVELS OF TRACE ELEMENTS AND ELECTROLYTES IN HYP ERTENSIVE PATIENTS
The involvement of elements in the pathological process of primary hypertension has been established. The serum levels of copper, iron, zinc, sodium, potassium and calcium were studied by atomic absorption spectrophotometery and flame photometry in hypertensive and normal subjects. Serum copper and zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively) as compar...
متن کاملThe effect of IntralipidB infusion on the human leucocyte sodium-pump in vivo
1. The effect of unsaturated long-chain non-esterified fatty acids (NEFA) on the human leucocyte sodiumpump was studied in vivo. 2. Plasma NEFA level was raised acutely from 0.28 (SD 0.10) to 2.54 (SD 0.48) mmol/l by infusion of 'Intralipid 20%' (trademark) at 90 ml/h with heparin, and the human leucocyte 22Na efflux rate constants were studied in eight normal weight males. 3. After 3 h, there ...
متن کامل